What is Prolotherapy

March, 2020 regenerative medicine

Prolotherapy is derived from the term proliferation, which means injections of cell growth factors or stimuli to produce cell growth factors that stimulate tissue growth and repair. Growth factors are protein molecules (polypeptides) that stimulate tissue to cell migration, growth and enhance cellular structure, protein synthesis and ultimately tissue repair.

Prolotherapy involves two main ways :

1) An in vitro preparation of growth factor is then injected into the target tissue for the tissue repair process.

2) The second method is stimulation to produce growth factor, in which solutions are injected that stimulate growth factor production, examples of which include dextrose injection, inflammatory compounds (to initiate the inflammatory cascade to produce growth factor).

Prolotherapy indications :

  • Tendon and Muscle Injury
  • Joint instability
  • Osteoarthritis
  • Spondylolisthesis
  • Lumbar, back and neck pain after surgery
  • Low back Pain with resistance to steroids, non-steroidal anti-inflammatory drugs, and RF .
  • Improving conditions for physiotherapy and massage therapies.
  • Intradiscal procedures.


Contraindications :

  • Sensitivity to anesthetics
  • Bacterial infection
  • Bleeding due to illness or taking anticoagulants
  • Malignant lesions of the muscle and bone tissue


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