Orthokin Therapy

March, 2020 regenerative medicine

What is Orthokin ? Autologous Conditioned Serum / ACS is produced under the trade name “Orthokin / Orthokin”. Orthokin therapy is a new and up-to-date method for the treatment of osteoarthritis that cleverly works out the cause of osteoarthritis and prevents the inflammatory process and pain associated with diseases of the joint and soft tissue.

The technique originated in Germany and is now recognized as one of the best and most effective methods of controlling and treating osteoarthritis with extremely brilliant results. Patients can benefit from orthokin therapy by referring to a pain specialist. With orthokin therapy, the symptoms and problems of arthritis such as pain, swelling, restriction of movement, etc. can be fully controlled and treated with consecutive treatment sessions. The effects of orthokin  treatment on the treatment of common arthritis (knee / hip / ankle / shoulder, etc.) are tremendous and can prevent many joint surgeries. Due to the unique anti-inflammatory effect of “orthokine”, it is also very effective in treating tendons and damaged muscles. In addition, this new treatment is used for disc problems, arthritis, or spinal stenosis (all of which have inflammatory problems).


In the 1990s, the key role of IL-1 was known to cause osteoarthritis and inflammation, and an attempt was made to find an injectable substance capable of inhibiting IL-1, which eventually became It resulted in the production of ACS orartokinin, which reduced the process of joint destruction and pain, tendon and muscle injuries and spinal canal problems. In this procedure, the patient’s blood is taken, processed , and the biological inhibitor protein “IL-1” is extracted and injected into the area with pain and inflammation. It focuses on the body’s ability to heal damaged tissue and is a minimal invasive procedure.

Method of orthokine preparation
Method of orthokine preparation

Method of orthokine preparation

According to the figure above,in sterile condition the patient’s placed in 10-ml sterile tube-like kits, and then the sample is incubated in an incubator for 12 to 24 hours until processed. The IL-1 inhibitor protein is produced by IL-1, then isolated from other blood components using a protein centrifuge and then drawn into a syringe and stored in the freezer at minus – 20 ° C. The view is removed from the freezer and injected into the affected area.

Uses of Orthokin Therapy

Orthokin therapy is used in the treatment of a wide range of diseases of the joints, skeletal tissue and spine, including :

1/Osteoarthritis (Osteoarthritis):

In degenerative  changes of the joints such as knee arthritis, pelvis, shoulder and … Orthokinotherapy is one of the most effective and useful methods. (6 injections required).

2/ Musculoskeletal system :

Trauma to the musculoskeletal system, occupational diseases or injuries to athletes and intense physical activity, cause damage,rupture and inflammation of the tendons, ligaments, wrists and muscles that can be repaired  with orthokine therapy at the site of injury.   (6 injections required).

3/Spinal vertebrae degeneration:

Degenerative changes in the intervertebral joints are associated with inflammation, with orthokin pain specialist can  control the problems.

Benefits of Orthokin Therapy

Orthokin is an autologous serum that is derived from the patient’s own blood and has no additives thus has no specific adverse effects. Interleukin-1 is said to cause damage, inflammation and  consequently  pain in the affected area.

Orthokinin has anti-inflammatory, analgesic and restorative effects, so it will clinically improve  the range of motion of the joints and improve activity.

Case selection for orthokin therapy

Treatment of knee osteoarthritis
Treatment of knee osteoarthritis

Apart from the use of orthokine therapy in degenerative changes of the spine and inflammation and rupture of the muscles, the most important use of orthokine  is in joints osteoarthritis.

Osteoarthritis is usually divided into four stages.In osteoarthritis,destruction of  the articular cartilage of the bones and reduction in joint space occurs.As can be seen in the figure above, orthokine therapy has a very high therapeutic effect from stages 1 to 3 osteoarthritis. But stage 4 osteoarthritis is the advanced stage of arthritis, where there is not bones space  and patients are candidates for joint replacement but people with concomitant diseases and anesthesia risk factors, low age for joint replacement ( short life of replacement joints) or unwillingness suegery can also be used in osteoarthritis stage 4, but its success rate may not be as high as 1 to 3 degrees.

Orthokine therapy steps

To initiate orthokinotherapy, the patient is first evaluated at our orthokin therapy center in Tehran and after the required imaging and the degree of arthritis, the severity of the problem is determined. The number of injection sessions is then determined and the number of orthokinetic kits required based on the number of joints destroyed. The number of sessions for arthritis, joints, tendons and tendons ruptures will be 6 sessions and for the spine 4 sessions. Blood sampling is then performed in a laboratory and orthokine samples are prepared within 24 hours. All samples are stored at minus  -20 degrees Celsius.

At each injection session, the required number of orthokine samples are removed from the freezer and the sample is thawed and then injected into the injury site by guidance of radiology (fluoroscopy) and ultrasound in the operating room. These injections are performed in the form of local anesthesia and the patient is fully conscious. Typically, injections are given once or twice a week.

After an injection, it is recommended that no intense activity be performed for up to 24 hours. Occasionally, there may be some swelling and numbness after the injection, which is resolved within hours and requires no special action. Since orthokine therapy is a less invasive procedure and is produced by the body’s own blood, fortunately it has no side effects. 

Picture of orthokin injection by Dr. Kazemi

Orthokinotherapy for hip arthritis
Orthokinotherapy for hip arthritis
Orthokinotherapy for knee arthritis
Orthokinotherapy for knee arthritis
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